2011

 

 

 

Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.,... Xiong, Y. (2011). Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases. Cancer Cell, 19(1), 17-30. doi: https://doi.org/10.1016/j.ccr.2010.12.014

 

 

 

Lv, L., Li, D., Zhao, D., Lin, R., Chu, Y., Zhang, H.,... Lei, Q. (2011). Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell, 42(6), 719-730. doi: https://doi.org/10.1016/j.molcel.2011.04.025

 

 

 

Liu, C., Lv, X., Li, T., Xu, Y., Zhou, X., Zhao, S.,... Guan, K. (2011). PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ. Journal of Biological Chemistry, 286(7), 5558-5566. doi: 10.1074/jbc.M110.194019

 

 

 

Jiang, W., Wang, S., Xiao, M., Lin, Y., Zhou, L., Lei, Q.,... Zhao, S. (2011). Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase. Molecular Cell, 43(1), 33-44. doi: https://doi.org/10.1016/j.molcel.2011.04.028

 

 

 

Chen, Y., Zhang, J., Lin, Y., Lei, Q., Guan, K. L., Zhao, S.,... Xiong, Y. (2011). Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep, 12(6), 534-541. doi: 10.1038/embor.2011.65

 

 

 

 

 

2014

 

 

 

Zhao, D., Mo, Y., Li, M., Zou, S., Cheng, Z., Sun, Y.,... Lei, Q. (2014). NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. Journal of Clinical Investigation, 124(12), 5453-5465. doi: 10.1172/JCI76611

 

 

 

Yang, H., Lin, H., Xu, H., Zhang, L., Cheng, L., Wen, B.,... Ye, D. (2014). TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Research, 24(8), 1017-1020. doi: 10.1038/cr.2014.81

 

 

 

Xu, Y., Li, F., Lv, L., Li, T., Zhou, X., Deng, C. X.,... Xiong, Y. (2014). Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase. Cancer Research, 74(13), 3630-3642. doi: 10.1158/0008-5472.CAN-13-3615

 

 

 

Wang, Y. P., Zhou, L. S., Zhao, Y. Z., Wang, S. W., Chen, L. L., Liu, L. X.,... Ye, D. (2014). Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and  cell survival during oxidative stress. EMBO J, 33(12), 1304-1320. doi: 10.1002/embj.201387224

 

 

 

Li, T., Liu, M., Feng, X., Wang, Z., Das, I., Xu, Y.,... Lei, Q. (2014). Glyceraldehyde-3-phosphate Dehydrogenase Is Activated by Lysine 254 Acetylation in Response to Glucose Signal. Journal of Biological Chemistry, 289(6), 3775-3785. doi: 10.1074/jbc.M113.531640

 

 

 

 

 

2020

 

 

 

 

Cheng, Z. L. , Zhang, M. L., Lin, H. P. ,. . . Xiong, Y., Zhang, M. L., Ye, D. (2020). The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Rep, 32(2):107877.doi: 10.1016/j.celrep.2020.107877

 

 

 

Li, X., Wang, T. X., Huang, X., Li, Y., Sun, T., Zang, S., . . . Yuan, H. X. (2020). Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver Int, 40(6), 1378-1394. doi:10.1111/liv.14428

Publications

 

 

2019

 

 

 

Wang, T. X., Liang, J. Y., Zhang, C., Xiong, Y., Guan, K. L., & Yuan, H. X. (2019). The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis, 10(10), 755. doi:10.1038/s41419-019-1984-4

 

 

 

Zhang, M., Wu, J., Sun, R., Tao, X., Wang, X., Kang, Q., . . . Ye, D. (2019). SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress. PLoS One, 14(2), e0211796. doi:10.1371/journal.pone.0211796

 

 

 

Xu, H., Xia, Y. K., Li, C. J., Zhang, J. Y., Liu, Y., Yi, W., . . . Mao, Y. (2019). Rapid diagnosis of IDH1-mutated gliomas by 2-HG detection with gas chromatography mass spectrometry. Lab Invest, 99(4), 588-598. doi:10.1038/s41374-018-0163-z

 

 

 

 

 

2018

 

 

 

Chen, L. L., Lin, H. P., Zhou, W. J., He, C. X., Zhang, Z. Y., Cheng, Z. L., . . . Guan, K. L. (2018). SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response. Cell Rep, 25(6), 1485-1500.e1484. doi:10.1016/j.celrep.2018.10.028

 

 

 

Liu, M. X., Jin, L., Sun, S. J., Liu, P., Feng, X., Cheng, Z. L., . . . Xiong, Y. (2018). Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene, 37(12), 1637-1653. doi:10.1038/s41388-017-0070-6

 

 

 

Li, F. L., Liu, J. P., Bao, R. X., Yan, G., Feng, X., Xu, Y. P., . . . Yuan, H. X. (2018). Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun, 9(1), 508. doi:10.1038/s41467-018-02950-5

 

 

 

Chen, X. F., Tian, M. X., Sun, R. Q., Zhang, M. L., Zhou, L. S., Jin, L., . . . Ye, D. (2018). SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep, 19(5). doi:10.15252/embr.201745124

 

 

 

 

 

2017

 

 

 

Mo, Y., Lin, R., Liu, P., Tan, M., Xiong, Y., Guan, K. L., & Yuan, H. X. (2017). SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J, 284(21), 3619-3636. doi:10.1111/febs.14259

 

 

 

Lin, R., Mo, Y., Zha, H., Qu, Z., Xie, P., Zhu, Z. J., . . . Guan, K. L. (2017). CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Mol Cell, 68(1), 198-209.e196. doi:10.1016/j.molcel.2017.09.008

 

 

 

Ma, S., Sun, R., Jiang, B., Gao, J., Deng, W., Liu, P., . . . Guan, K. L. (2017). L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol, 37(8). doi:10.1128/mcb.00492-16

 

 

 

Wang, Z., Liu, P., Zhou, X., Wang, T., Feng, X., Sun, Y. P., . . . Guan, K. L. (2017). Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Res, 77(9), 2413-2423. doi:10.1158/0008-5472.Can-16-3229

 

 

 

 

 

2016

 

 

 

Han, X. R., Zha, Z., Yuan, H. X., Feng, X., Xia, Y. K., Lei, Q. Y., . . . Xiong, Y. (2016). KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation. Oncogene, 35(32), 4179-4190. doi:10.1038/onc.2015.482

 

 

 

Zha, Z., Han, X. R., Smith, M. D., Lei, Q. Y., Guan, K. L., & Xiong, Y. (2016). Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination. Cell Discov, 2, 16005. doi:10.1038/celldisc.2016.5

 

 

 

Lin, H. P., Cheng, Z. L., He, R. Y., Song, L., Tian, M. X., Zhou, L. S., . . . Xiong, Y. (2016). Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. Cancer Res, 76(23), 6924-6936. doi:10.1158/0008-5472.Can-16-1597

 

 

 

Feng, X., Liu, P., Zhou, X., Li, M. T., Li, F. L., Wang, Z., . . . Guan, K. L. (2016). Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem, 291(36), 18947-18958. doi:10.1074/jbc.M116.739722

 

 

 

Zhou, L., Wang, F., Sun, R., Chen, X., Zhang, M., Xu, Q., . . . Ye, D. (2016). SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Rep, 17(6), 811-822. doi:10.15252/embr.201541643

 

 

 

 

Ye, D., & Xiong, Y. (2016). Cancer: Suffocation of gene expression. Nature, 537(7618), 42-43. doi:10.1038/nature19426[综述]

 

 

2015

 

 

 

Yuan, H. X., Wang, Z., Yu, F. X., Li, F., Russell, R. C., Jewell, J. L., & Guan, K. L. (2015). NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev, 29(22), 2362-2376. doi:10.1101/gad.265116.115

 

 

 

Wang, P., Wu, J., Ma, S., Zhang, L., Yao, J., Hoadley, K. A., . . . Xiong, Y. (2015). Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep, 13(11), 2353-2361. doi:10.1016/j.celrep.2015.11.029

 

 

 

Lv, X. B., Liu, C. Y., Wang, Z., Sun, Y. P., Xiong, Y., Lei, Q. Y., & Guan, K. L. (2015). PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep, 16(8), 975-985. doi:10.15252/embr.201439951

 

 

 

Wang, S., Jiang, B., Zhang, T., Liu, L., Wang, Y., Wang, Y., . . . Guan, K. L. (2015). Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol, 13(9), e1002243. doi:10.1371/journal.pbio.1002243

 

 

 

Zhou, X., Wang, S., Wang, Z., Feng, X., Liu, P., Lv, X. B., . . . Guan, K. L. (2015). Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest, 125(5), 2123-2135. doi:10.1172/jci79573

 

 

 

Zha, Z., Han, X., Smith, M. D., Liu, Y., Giguère, P. M., Kopanja, D., . . . Xiong, Y. (2015). A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Mol Cell, 58(5), 794-803. doi:10.1016/j.molcel.2015.04.017

 

 

 

Yang, H., Zhou, L., Shi, Q., Zhao, Y., Lin, H., Zhang, M.,... Ye, D. (2015). SIRT3‐dependent GOT2 acetylation status affects the malate–aspartate NADH shuttle activity and pancreatic tumor growth. The EMBO Journal, 34(8), 1110-1125. doi: 10.15252/embj.201591041

 

 

 

Wang, Y., Xiao, M., Chen, X., Chen, L., Xu, Y., Lv, L.,... Xiong, Y. (2015). WT1 Recruits TET2 to Regulate Its Target Gene Expression and Suppress Leukemia Cell Proliferation. Molecular Cell, 57(4), 662-673. doi: 10.1016/j.molcel.2014.12.023

 

 

 

Ma, S., Jiang, B., Deng, W., Gu, Z. K., Wu, F. Z., Li, T.,... Guan, K. L. (2015). D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarget, 6(11), 8606-8620. doi: 10.18632/oncotarget.3330

 

 

2013

 

 

 

Zhao, D., Zou, S., Liu, Y., Zhou, X., Mo, Y., Wang, P.,... Guan, K. (2013). Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell, 23(4), 464-476. doi: https://doi.org/10.1016/j.ccr.2013.02.005

 

 

 

Yang, H., Liu, Y., Bai, F., Zhang, J. Y., Ma, S. H., Liu, J.,... Xiong, Y. (2013). Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene, 32(5), 663-669. doi: 10.1038/onc.2012.67

 

 

 

Lv, L., Xu, Y., Zhao, D., Li, F., Wang, W., Sasaki, N.,... Xiong, Y. (2013). Mitogenic and Oncogenic Stimulation of K433 Acetylation Promotes PKM2 Protein Kinase Activity and Nuclear Localization. Molecular Cell, 52(3), 340-352. doi: https://doi.org/10.1016/j.molcel.2013.09.004

 

 

 

Lin, R., Tao, R., Gao, X., Li, T., Zhou, X., Guan, K.,... Lei, Q. (2013). Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth. Molecular Cell, 51(4), 506-518. doi: https://doi.org/10.1016/j.molcel.2013.07.002

 

 

 

 

 

2012

 

 

 

Zhou, X., Li, T., Feng, X., Hsiang, E., Xiong, Y., Guan, K.,... Lei, Q. (2012). Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochemical Journal, 441(1), 227-236. doi: 10.1042/BJ20111500

 

 

 

Zhang, T., Wang, S., Lin, Y., Xu, W., Ye, D., Xiong, Y.,... Guan, K. (2012). Acetylation Negatively Regulates Glycogen Phosphorylase by Recruiting Protein Phosphatase 1. Cell Metabolism, 15(1), 75-87. doi: https://doi.org/10.1016/j.cmet.2011.12.005

 

 

 

Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H.,... Guan, K. L. (2012). Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes & Development, 26(12), 1326-1338. doi: 10.1101/gad.191056.112

 

 

 

Wang, P., Dong, Q., Zhang, C., Kuan, P., Liu, Y., Jeck, W. R.,... Chiang, D. Y. (2012). Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene, 32(25), 3091-3100. doi: 10.1038/onc.2012.315

 

 

 

Huang, W., Lv, X., Liu, C., Zha, Z., Zhang, H., Jiang, Y.,... Guan, K. (2012). The N-terminal Phosphodegron Targets TAZ/WWTR1 Protein for SCFβ-TrCP-dependent Degradation in Response to Phosphatidylinositol 3-Kinase Inhibition. Journal of Biological Chemistry, 287(31), 26245-26253. doi: 10.1074/jbc.M112.382036

 

 

2010

 

 

 

Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T.,... Guan, K. L. (2010). Regulation of cellular metabolism by protein lysine acetylation. Science, 327(5968), 1000-1004. doi: 10.1126/science.1179689

 

 

 

Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J.,... Zhao, G. P. (2010). Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science, 327(5968), 1004-1007. doi: 10.1126/science.1179687

 

 

 

Liu, C., Zha, Z., Zhou, X., Zhang, H., Huang, W., Zhao, D.,... Guan, K. (2010). The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase. Journal of Biological Chemistry, 285(48), 37159-37169. doi: 10.1074/jbc.M110.152942

 

 

 

 

 

 

 

 

 

2009

 

 

 

Zhao, S-M., Xu, W., Jiang, W-Q., Zha, Z-Y., Wang, P., Li, Z-Q., Gong, L-L., Peng, Y-J., Ding, J-P., Lei, Q-Y., Guan, K-L., Xiong, Y., (2009) Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1a. Science, 324:261-265

 

 

 

Zhang, H., Liu, C., Zha, Z., Zhao, B., Yao, J., Zhao, S.,... Guan, K. (2009). TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition. Journal of Biological Chemistry, 284(20), 13355-13362. doi: 10.1074/jbc.M900843200

 

 

 

Yu, W., Lin, Y., Yao, J., Huang, W., Lei, Q., Xiong, Y.,... Guan, K. (2009). Lysine 88 Acetylation Negatively Regulates Ornithine Carbamoyltransferase Activity in Response to Nutrient Signals. Journal of Biological Chemistry, 284(20), 13669-13675. doi: 10.1074/jbc.M901921200

 

 

 

 

 

2008

 

 

 

Lei, Q., Zhang, H., Zhao, B., Zha, Z., Bai, F., Pei, X.,... Guan, K. (2008). TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway. Molecular and Cellular Biology, 28(7), 2426-2436. doi: 10.1128/MCB.01874-07

 

Wang, P., Song, J., & Ye, D. (2020). CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases. Adv Exp Med Biol, 1217, 211-223. doi:10.1007/978-981-15-1025-0_13 [综述]

 

Ye, D., Guan, K. L., & Xiong, Y. (2018). Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates. Trends Cancer, 4(2), 151-165. doi:10.1016/j.trecan.2017.12.005 [综述]

 

Yuan, H. X., Xiong, Y., & Guan, K. L. (2013). Nutrient sensing, metabolism, and cell growth control. Mol Cell, 49(3), 379-387. doi:10.1016/j.molcel.2013.01.019 [综述]

 

 

 

Zhao, D., Xiong, Y., Lei, Q. Y., & Guan, K. L. (2013). LDH-A acetylation: implication in cancer. Oncotarget, 4(6), 802-803. doi:10.18632/oncotarget.1007 [综述]

 

 

 

Ye, D., Ma, S., Xiong, Y., & Guan, K. L. (2013). R-2-hydroxyglutarate as the key effector of IDH mutations promoting oncogenesis. Cancer Cell, 23(3), 274-276. doi:10.1016/j.ccr.2013.03.005 [综述]

 

 

 

Ye, D., Xiong, Y., & Guan, K. L. (2012). The mechanisms of IDH mutations in tumorigenesis. Cell Res, 22(7), 1102-1104. doi:10.1038/cr.2012.51 [综述]

 

 

 

Oermann, E. K., Wu, J., Guan, K. L., & Xiong, Y. (2012). Alterations of metabolic genes and metabolites in cancer. Semin Cell Dev Biol, 23(4), 370-380. doi:10.1016/j.semcdb.2012.01.013 [综述]

 

 

 

Yang, H., Ye, D., Guan, K. L., & Xiong, Y. (2012). IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin Cancer Res, 18(20), 5562-5571. doi:10.1158/1078-0432.Ccr-12-1773 [综述]

 

 

 

Xiong, Y., & Guan, K. L. (2012). Mechanistic insights into the regulation of metabolic enzymes by acetylation. J Cell Biol, 198(2), 155-164. doi:10.1083/jcb.201202056 [综述]

 

 

 

Xiong, Y., Lei, Q. Y., Zhao, S., & Guan, K. L. (2011). Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK. Cold Spring Harb Symp Quant Biol, 76, 285-289. doi:10.1101/sqb.2011.76.010942 [综述]

 

 

 

Guan, K. L., & Xiong, Y. (2011). Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci, 36(2), 108-116. doi:10.1016/j.tibs.2010.09.003 [综述]

 

 

 

Guan, K. L., Yu, W., Lin, Y., Xiong, Y., & Zhao, S. (2010). Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc, 5(9), 1583-1595. doi:10.1038/nprot.2010.117 [综述]

 

 

 

Zhao, B., Lei, Q-Y., Guan, K-L., (2008) The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion Cell Biology, 20:638-46 [综述]

 

 

 

Zhao, S., & Guan, K. L. (2008). Substrate selectivity APPLies to Akt. cell, 133(3), 399-400. doi:10.1016/j.cell.2008.04.015 [综述]

 

 

2021

 

 

 

Xia, Y. K. , Zeng, Y. R., Zhang, M. L.,. . . Guan, K. L., Xiong, Y., Ye, D. (2021). Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Protein Cell, 12(7):557–577.doi: 10.1007/s13238-020-00754-2

 

 

Liu, P. , Liu, J. P., Sun, S. J.,. . . Liu, Y., Xiong, Y., Yuan, H. X. (2021).CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML. Front Cell Dev Biol, 2021 Jul 15;9:675424. doi: 10.3389/fcell.2021.675424

 

 

 

Bao, R. X. , Meng, Y. M., Zhang, H. B.,. . . Zhang, C. S., Yuan, H. X., Dang, Y. J.(2021). Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death Dis,2021 Oct 20;12(11):972. doi: 10.1038/s41419-021-04264-9

 

 

2022

 

 

 

Sun, S. J. , Ai, Y. J., Duan, K. L.,. . . Xiong, Y., Guan, K. L., Yuan, H. X. (2022). TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression. Oncogene, 2022 Dec;41(50):5385-5396. doi: 10.1038/s41388-022-02531-3

 

 

Wang, T. X. , Duan, K. L., Huang, Z. X. ,. . . Ding, C. Y., Guan, K. L., Yuan, H. X. (2022). Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis. Life Sci Alliance, 2022 Nov 1;6(1):e202201667. doi: 10.26508/lsa.202201667

 

 

Hu, M. N. , Bao, R. X., Miao, L. ,. . . Guan, K. L., Xiong, Y., Yuan, H. X. (2022). ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3. Oncogene, 2022 Sep;41(40):4547-4559. doi: 10.1038/s41388-022-02453-0

 

 

Wang, X. Y. , Zhu, W. W., Wang, Z. ,. . . Ye, D., Qin, L. X. (2022). Driver mutations of intrahepatic cholangiocarcinoma shape clinically relevant genomic clusters with distinct molecular features and therapeutic vulnerabilities. Theranostics, 2022 Jan 1;12(1):260-276. doi: 10.7150/thno.63417.

 

 

Chen, L. L. , Carmen Morcelle, Cheng, Z. L.,. . . Guan, K. L., Xiong, Y., Ye, D. (2022).Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses. Nat Cell Biol, 2022 Mar;24(3):353-363. doi: 10.1038/s41556-022-00853-8

 

 

Sun, R. Q. , Zhang, Z. Y., Bao, R. X. ,. . . Shi, Y. H., Wang, P., Ye, D. (2022).Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis. J Hepatol,2022 Mar 12;S0168-8278(22)00139-8. doi: 10.1016/j.jhep.2022.02.030

 

 

Liu, P. , Sun, S. J., Ai, Y. J.,. . . Lin, M., Xiong, Y., Yuan, H. X. (2022).Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance. Cell Death Dis,2022 Mar 4;13(3):205. doi: 10.1038/s41419-022-04655-6

 

 

Chen, X. F. , Zhou, W. J., Song, R. H.,. . . Chen, T., Li, Y., Ye, D. (2022).Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity. Sci Adv,2022 Jan 28;8(4):eabl5220. doi: 10.1126/sciadv.abl5220

 

 

2023

 

 

 

Chen, Y. J., Li, G. N., Li, X. J., Wei, L. X., Fu, M. J., Cheng, Z. L., ... & Chen, L. L. (2023). Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy. Sci Adv,2023 Apr 28;9(17):eadg0654. doi: 10.1126/sciadv.adg0654.

 

 

Zeng, Y. R. , Song, J. B., Wang, D. Z. ,. . . Guan, K. L., Ye, D., Wang, P. (2023). The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response. J Clin Invest, 2023 Mar 15;133(6):e160463. doi: 10.1172/JCI160463.