实验室成员

实验室成员 -- 导师

叶丹

 

博士，研究员，博导，国自然优青，教育部青年长江，国家杰青

 

 

办公室电话：54237834

          传真：54237450

实验室电话：54237832

Email：yedan@fudan.edu.cn

叶丹，博士，研究员，博导，国自然优青，教育部青年长江，国家杰青

 

2002年毕业于浙江大学获理学学士学位，2005年毕业于浙江大学获遗传学硕士学位，2008年毕业于荷兰莱顿大学（Leiden University）获生物制药博士学位， 2008-2010年在莱顿大学阿姆斯特丹/莱顿药物研发中心做博士后，关注脂类代谢异常影响巨噬细胞功能及心血管病发生（Circ Res, Arterioscler Thromb Vasc Biol等）。2011年受聘复旦大学，全职回国工作，长期从事代谢和表观遗传交互调控机理与功能研究，系统探讨代谢与表观遗传重编程在恶性肿瘤等重大疾病演进中的异变。

 

研究方向：代谢与表观遗传重编程决定基因转录

（1）代谢的上游调控机理，关注酰基化等蛋白翻译后修饰通过不同机制调控关键代谢酶活性及功能，介导细胞对能量供给、氧化应激等外界环境因素响应，为靶向代谢干预的肿瘤和先天性代谢缺陷等疾病治疗提供思路。

（2）代谢下游生物学效应，关注生理及病理条件下异常积累的代谢物，其作为信号分子动态影响表观遗传修饰酶活性，调控靶基因转录和信号通路、基因组稳定性等，剖析代谢和表观遗传重编程促进细胞恶性转化的核心机理，并发现基于代谢和表观遗传的新型肿瘤标志物、潜在干预靶标。

  

迄今，以第一或通讯作者在国际知名期刊发表SCI论文27篇。其中， 22篇为通讯作者（含共同）论文，刊登在Nat Cell Biol、Journal of Hepatology、Mol cell、Cell Res、Sci Adv、Genes Dev、EMBO J (2篇)、Cancer Res、Cell Rep (3篇)、EMBO Rep (2篇) 等。总他引3015次（2篇ESI高被引论文）。成果被Cancer Discov、Mol Cell、EMBO J、PLoS Biol等期刊专评。以第一或共同通讯作者在Nature、Cancer Cell等发表述评和综述4篇，并多次担任Nature、Cancer Cell、Nat Cell Biol等审稿人。在全球华人生物学家大会、中国细胞生物学学会等国际学术会议做大会及分会报告。现任中国抗癌协会肿瘤代谢专业委员会全国常委。

 

办公室电话：54237834

Email：yedan@fudan.edu.cn

 

 

近年代表性论文：（全部作者，文章名，期刊名，年，卷期，页；*通讯，#共一)

  1. Renqiang Sun, Zhiyong Zhang, Ruoxuan Bao, Xiaozhen Guo, Yuan Gu, Wenjing Yang, Jinsong Wei, Xinyu Chen, Lingfeng Tong, Jian Meng, Chen Zhong, Cheng Zhang, Jinye Zhang, Yiping Sun, Chen Ling, Xuemei Tong, Fa-Xing Yu, Hongxiu Yu, Weifeng Qu, Bing Zhao, Wei Guo, Maoxiang Qian, Hexige Saiyin, Ying Liu, Rong-Hua Liu, Cen Xie, Weiren Liu, Yue Xiong, Kun-Liang Guan, Yinghong Shi, Pu Wang1,11, Dan Ye*. Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis. Journal of Hepatology.2022; In press.
  2. Lei-Lei Chen#, Carmen Morcelle#, Zhou-Li Cheng#, Xiufei Chen, Yanping Xu, Yajing Gao, Junbin Song, Zhijun Li, Matthew D. Smith, Miao Shi, Yezhang Zhu, Neng Zhou, Meng Cheng, Chenxi He, Kwei-Yan Liu, Guoping Lu, Lei Zhang, Chen Zhang, Jingye Zhang, Yiping Sun, Tuan Qi, Yingying Lyu, Zhi-Zhong Ren, Xian-Ming Tan, Jiayong Yin, Fei Lan, Ying Liu, Hui Yang, Maoxiang Qian, Caiwen Duan, Xing Chang, Yufeng Zhou, Li Shen, Albert S. Baldwin, Kun-Liang Guan, Yue Xiong, and Dan Ye.* Itaconate Inhibits TET DNA Dioxygenases to Dampen Inflammatory Responses. Nature Cell Biology.2022 Mar;24(3):353-363.
  3. Xiufei Chen#, Wenjie Zhou#, Ren-Hua Song#, Shuang Liu#, Shu Wang, Yujia Chen, Chao Gao, Chenxi He, Jianxiong Xiao, Lei Zhang, Tianxiang Wang, Peng Liu, Kunlong Duan, Zhouli Cheng, Chen Zhang, Jinye Zhang, Yiping Sun, Felix Jackson, Fei Lan, Yun Liu, Yanhui Xu, Justin Jong-Leong Wong, Pu Wang, Hui Yang, Yue Xiong, Tong Chen*, Yan Li*, Dan Ye.* Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity. Science Advances. 2022 Jan 28;8(4):eabl5220.
  4. Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan KL, Xiong Y, Zhang M*, Ye D*. The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Reports. 2020;32(2):107877.
  5. Lei-Lei Chen#, Huai-Peng Lin#, Wen-Jie Zhou, Chen-Xi He, Zhi-Yong Zhang, Zhou-Li Cheng, Jun-Bin Song, Peng Liu, Xin-Yu Chen, Yu-Kun Xia, Xiu-Fei Chen, Ren-Qiang Sun, Jing-Ye Zhang, Yi-Ping Sun, Lei Song, Bing-Jie Liu, Rui-Kai Du, Chen Ding, Fei Lan, Sheng-Lin Huang, Feng-Zhou, Su-Ling Liu, Yue Xiong*, Dan Ye*, and Kun-Liang Guan*. SNIP1 recruits TET2 to regulate c-MYC target genes and cellular DNA damage response. Cell Reports. 2018;25(6):1485-1500.
  6. D Ye*, KL Guan, Y Xiong*. Metabolism, Activity, and Targeting of D-and L-2-Hydroxyglutarates. Trends in Cancer. 2018;4(2):151-165 (Invited review)
  7. Huai-Peng Lin, Zhou-Li Cheng, Ruo-Yu He, Lei Song, Meng-Xin Tian, Lisha Zhou, Beezly S. Groh, Weiren Liu, Min-Biao Ji, Chen Ding, Ying-Hong Shi, Kun-Liang Guan*, Dan Ye*, and Yue Xiong*. Destabilization of fatty acid synthase by acetylation inhibits de novo lipogenesis and tumor cell growth. Cancer Research. 2016; 76, 6924-36.
  8. Ye D*, Xiong Y*. Cancer: Suffocation of gene expression. Nature. 2016;537(7618):42-43. (Invited Preview)
  9. Wang P, Wu J, Ma S-H, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan K-L*, Ye D*, Xiong Y. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Reports. 2015;13(11):2353-61.
  10. Wang S-W, Jiang B-W, Zhang T-F, Liu L-X, Wang Y, Wang Y-P, Chen X-F, Lin H-P, Zhou L-S, Xia Y-K, Chen L-L, Yang C, Xiong Y*, Ye D*, Guan K-L.* Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biology. 2015;13(9):e1002243. (Previewed by PLoS Biology)
  11. Hui Yang#, Lisha Zhou#, Qian Shi, Yuzheng Zhao, Huaipeng Lin, Mengli Zhang, Yi Yang, Zhi-Qiang Ling, Kun-Liang Guan*, Yue Xiong*, and Dan Ye*. SIRT3-dependent GOT2 acetylation enhances the malate-aspartate NADH shuttle activity to promote pancreatic tumor growth. EMBO J. 2015;34(8):1110-25.
  12. Wang Y-P, Xiao M-T, Chen X-F, Chen L-L, Xu Y-P, Lv L, Wang P, Yang H, Ma S-H, Lin H-P, Jiao B, Ren R-B, Ye D*, Guan, K-L*, and Xiong Y*. WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell. 2015; 57(4):662-73. (Previewed by Mol Cell)
  13. Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D*. Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress. EMBO J. 2014; 33(12):1304-20. (Previewed by EMBO J)
  14. Yang H. Lin H-P, Xu H-Y, Zhang L, Cheng L, Wen B, Shou J-Y, Guan K-L, Xiong Y, Ye D*. TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Research. 2014;24(8):1017-20.
  15. Yang H#, Liu Y#, Bai F, Zhang J-Y, Ma S-H, Liu J, Xu Z-D, Zhu H-G, Ling Z-Q, Ye D*, Guan K-L* and Xiong Y*. Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene. 2013; 32(5):663-9. (入选ESI高被引论文)
  16. Ye D, Ma S-H, XiongY, GuanK-L*. R-2-Hydroxyglutarate as the Key Effector of IDH Mutations Promoting Oncogenesis. Cancer Cell. 2013; 23(3):274-276. (Invited Preview)
  17. Ye D*, Guan K-L* and Xiong Y*. The mechanisms of IDH mutations in tumorigenesis. Cell Research. 2012; 22 (7):1102-4. (Invited review)
  18. Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D*, Xiong Y*, Guan KL.Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes & Development. 2012; 26(12):1326-1338. (入选ESI高被引论文)