陈磊蕾

博士，青年副研究员

实验室电话：54237832

Email：chenleilei@fudan.edu.cn

陈磊蕾 博士，青年副研究员

2013年毕业于华中农业大学获学士学位，2018年毕业于复旦大学获博士学位， 2018-2020年在北卡罗莱纳大学/莱恩博格肿瘤研究中心做博士后，从事代谢免疫及表观遗传学机理方面的研究。2020年底受聘复旦大学，全职回国工作。围绕“代谢与免疫”,开展“代谢物调控肿瘤免疫”以及“代谢物通过影响表观遗传参与神经免疫”的相关研究。迄今，在Nature Cell biology,Science Advances, Cell Report, Nature (News & Views), Mol Cell, EMBO J等国际核心期刊发表多篇SCI论文。

实验室电话：54237832

Email：chenleilei@fudan.edu.cn

代表性论文（*通讯作者）

1.Chen, Y. J., Li, G. N., Li, X. J., Wei, L. X., Fu, M. J., Cheng, Z. L., ... & Chen, L. L. (2023). Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy. Science Advances, 9(17), eadg0654.

2.Chen, L. L., Morcelle, C., Cheng, Z. L., Chen, X., Xu, Y., Gao, Y., ... & Ye, D. (2022). Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses. Nature Cell Biology, 24(3), 353-363.

3.Chen, L. L., Smith, M. D., Lv, L., Nakagawa, T., Li, Z., Sun, S. C., ... & Xu, Y. P. (2020). USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2. Science advances, 6(38), eabc9730.

4.Chen, L. L., Lin, H. P., Zhou, W. J., He, C. X., Zhang, Z. Y., Cheng, Z. L., ... & Guan, K. L. (2018). SNIP1 recruits TET2 to regulate c-MYC target genes and cellular DNA damage response. Cell reports, 25(6), 1485-1500.

5.Chen, L. L., & Xiong, Y. (2020). Tumour metabolites hinder DNA repair. Nature (News & Views).

6.Wang, Y., Xiao, M., Chen, X., Chen, L., Xu, Y., Lv, L., ... & Xiong, Y. (2015). WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Molecular cell, 57(4), 662-673.

7.Wang, Y. P., Zhou, L. S., Zhao, Y. Z., Wang, S. W., Chen, L. L., Liu, L. X., ... & Ye, D. (2014). Regulation of G 6 PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. The EMBO journal, 33(12), 1304-1320.